No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

Objective Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine i...

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Published in:Obesity (Silver Spring, Md.) Md.), 2013-09, Vol.21 (9), p.1803-1806
Main Authors: Thomsen, G., Ziebell, M., Jensen, P. S., Cuhna‐Bang, S., Knudsen, G. M., Pinborg, L. H.
Format: Article
Language:English
Subjects:
Addictions
Adult
Aged
Binding sites
BMI
Body Mass Index
Brain - metabolism
Corpus Striatum - metabolism
Dopamine
Dopamine - metabolism
Dopamine Plasma Membrane Transport Proteins - metabolism
Dopamine transporter
Ethics
Female
Health care
Healthy Volunteers
human
Humans
Hypotheses
Linear Models
Male
Methamphetamine
Middle Aged
Neurosciences
Obesity
Obesity - metabolism
Reference Values
SPECT
Studies
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Summary:Objective Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values. Design and Methods Thirty‐three healthy subjects with a mean age of 48.4 ± 13.3 (range, 21‐71) years and a mean BMI of 29.6 ± 7.8 kg/m2 (range, 21.0‐49.5) were included in the study. We used [123I]PE2I and SPECT to measure DAT availability. Results Using multiple linear regression analyses with striatal DAT as the dependent variable and BMI, age and gender as predictors was performed. We found no correlation between BMI and striatal DAT availability in striatum (P = 0.99), caudate nucleus (P = 0.61), and putamen (P = 0.30). Furthermore, we found no group difference between obese/severely obese (BMI > 30 kg/m2) and normal weight controls (BMI ≤ 25 kg/m2). Conclusions We did not find any correlation between BMI and DAT availability in healthy volunteers.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.20225