Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues

HOTAIR is a known long non-coding RNA which has recently been associated with the progression of some cancer types. It has been reported that HOTAIR expression is correlated with SUZ 12 expression level and therefore may affect the epigenetic state of cancer tissues. Here, we found aberrant up-regul...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2013-09, Vol.30 (3), p.670-670, Article 670
Main Authors: Hajjari, Mohammadreza, Behmanesh, Mehrdad, Sadeghizadeh, Majid, Zeinoddini, Mehdi
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Disease Progression
Female
Hematology
Humans
Internal Medicine
Lymphatic Metastasis - genetics
Lymphatic Metastasis - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Paper
Pathology
Polycomb Repressive Complex 2 - genetics
RNA, Long Noncoding - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Up-Regulation - genetics
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Summary:HOTAIR is a known long non-coding RNA which has recently been associated with the progression of some cancer types. It has been reported that HOTAIR expression is correlated with SUZ 12 expression level and therefore may affect the epigenetic state of cancer tissues. Here, we found aberrant up-regulation of HOTAIR in gastric adenocarcinoma samples compared with normal adjacent gastric epithelium tissues. Besides, we found that the aberrant expression of HOTAIR was associated with TNM staging and lymph node metastasis of gastric tumors. Here, a potential cooperative expression between HOTAIR and SUZ 12 genes in gastric adenocarcinoma tissues is deduced. This result suggests a role for HOTAIR long non-coding RNA in gastric cancer progression.
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-013-0670-0