Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination. e71376

Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipie...

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Bibliographic Details
Published in:PloS one 2013-08, Vol.8 (8)
Main Authors: Moss, Alastair J, Gaughran, Fiona P, Karasu, Aliyye, Gilbert, Anthony S, Mann, Alex J, Gelder, Colin M, Oxford, John S, Stephens, Henry A, Lambkin-Williams, Rob
Format: Article
Language:English
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Summary:Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04:01 and HLA-DPB1*04:01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
ISSN:1932-6203
DOI:10.1371/journal.pone.0071376