[beta] sub(LG) values in mechanistic studies on the transesterification of RNA models and their application in a metal ion complex promoted transesterification

Studies on the mechanism of transesterification reactions of nucleoside 3'-phosphoesters using [beta] sub(LG) values as a mechanistic tool are discussed in this mini review. Our recent observation that a dinuclear metal ion complex enhances both the cleavage and isomerisation is discussed in th...

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Bibliographic Details
Published in:Journal of physical organic chemistry 2013-02, Vol.26 (2), p.182-186
Main Authors: Korhonen, Heidi, Williams, Nicholas H, Mikkola, Satu
Format: Article
Language:English
Online Access:Get full text
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Summary:Studies on the mechanism of transesterification reactions of nucleoside 3'-phosphoesters using [beta] sub(LG) values as a mechanistic tool are discussed in this mini review. Our recent observation that a dinuclear metal ion complex enhances both the cleavage and isomerisation is discussed in the light of previous studies. Copyright [copy 2012 John Wiley & Sons, Ltd. [beta] sub(LG) values reported for the transesterification of phosphodiester bonds ribonucleoside 3'-alkyl and 3'-dialkyl phosphates under various conditions, as well as the mechanistic interpretation of the values, is discussed in this review.
ISSN:0894-3230
1099-1395
DOI:10.1002/poc.2942