Effect of Hyaluronate-Endo-β-N-Acetylhexosaminidase Pegylated by Electron Beam Synthesis Nanotechnology on the Formation of Hematological Shifts in Chronic Hepatitis

• Published in: Bulletin of experimental biology and medicine 2012-12, Vol.154 (2), p.278-282
• Main Authors: Dygai, A. M., Zyuz’kov, G. N., Gurto, R. V., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Simanina, E. V., Stavrova, L. A., Chaikovskii, A. V., Markova, T. S., Minakova, M. Yu, Artamonov, A. V., Bekarev, A. A., Madonov, P. G., Kinsht, D. N.
• Format: Article
• Language: English
• Subjects: Animals; beta-N-Acetylhexosaminidases - chemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Electrons; Hematopoiesis - drug effects; Hepatitis; Hepatitis, Chronic - drug therapy; Hepatitis, Chronic - metabolism; Hyaluronic acid; Hyaluronic Acid - chemistry; Internal Medicine; Laboratory Medicine; Male; Mice; Mice, Inbred C57BL; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Nanotechnology; Nanotechnology - methods; Pathology; Regenerative Medicine - methods; Stem cells
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1930-2

We studied the effect of mobilization of bone marrow multipotent stem cells induced by intragastric administration of pegylated hyaluronate-endo-β-N-acetylhexosaminidase (Peg-HEAHA) on hemopoiesis under conditions of experimental chronic hepatitis. Peg-HEAHA increased the counts of hemopoietic precursors in the hemopoietic tissue against the background of their decelerated maturation. This was paralleled by a short-term decrease in the count of neutrophilic granulocyte in the bone marrow and a slight increase of neutrophil count in the peripheral blood.