Bacopa monnieri Increases Cerebral Blood Flow in Rat Independent of Blood Pressure

Bacopa monnieri (L.) Wettst. (Brahmi in India and Thailand) is an ayurvedic dementia treatment, but its effect on cerebral blood flow (CBF) is still unknown. We sought to test its chronic and acute effects on CBF compared with Ginkgo biloba and donepezil. CBF was measured by laser Doppler from rat c...

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Bibliographic Details
Published in:Phytotherapy research 2013-01, Vol.27 (1), p.135-138
Main Authors: Kamkaew, Natakorn, Norman Scholfield, C., Ingkaninan, Kornkanok, Taepavarapruk, Niwat, Chootip, Krongkarn
Format: Article
Language:English
Subjects:
Animals
Bacopa - chemistry
Bacopa monnieri
Blood Pressure
cerebral blood flow
Cerebrovascular Circulation - drug effects
Ginkgo biloba
Ginkgo biloba - chemistry
Indans - pharmacology
Male
Nitroprusside - pharmacology
nootropic
Nootropic Agents
Norepinephrine - pharmacology
Piperidines - pharmacology
Plant Extracts - pharmacology
Rats
vasodilation
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Summary:Bacopa monnieri (L.) Wettst. (Brahmi in India and Thailand) is an ayurvedic dementia treatment, but its effect on cerebral blood flow (CBF) is still unknown. We sought to test its chronic and acute effects on CBF compared with Ginkgo biloba and donepezil. CBF was measured by laser Doppler from rat cerebral cortex after 8 weeks of daily oral dosing of these drugs. Systolic blood pressure was also measured using the tail cuff method or via arterial cannulation. In rats treated with B. monnieri (40 mg/kg), CBF was 25% increased [2927 ± 123 perfusion units, (PU)] compared with shams (2337 ± 217 PU, p 
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.4685