The effect of aerobic exercise on cortical architecture in patients with chronic schizophrenia: a randomized controlled MRI study

Via influencing brain plasticity, aerobic exercise could contribute to the treatment of schizophrenia patients. As previously shown, physical exercise increases hippocampus volume and improves short-term memory. We now investigated gray matter density and brain surface expansion in this sample using...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2013-09, Vol.263 (6), p.469-473
Main Authors: Falkai, Peter, Malchow, Berend, Wobrock, Thomas, Gruber, Oliver, Schmitt, Andrea, Honer, William G., Pajonk, Frank-Gerald, Sun, Frank, Cannon, Tyrone D.
Format: Article
Language:English
Subjects:
Adult
Brain Mapping
Cerebral Cortex - pathology
Exercise - physiology
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Neurosciences
Original Paper
Psychiatry
Schizophrenia - pathology
Schizophrenia - rehabilitation
Young Adult
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Summary:Via influencing brain plasticity, aerobic exercise could contribute to the treatment of schizophrenia patients. As previously shown, physical exercise increases hippocampus volume and improves short-term memory. We now investigated gray matter density and brain surface expansion in this sample using MRI-based cortical pattern matching methods. Comparing schizophrenia patients to healthy controls before and after 3 months of aerobic exercise training (cycling) plus patients playing table football yielded gray matter density increases in the right frontal and occipital cortex merely in healthy controls. However, respective exercise effects might be attenuated in chronic schizophrenia, which should be verified in a larger sample.
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-012-0383-y