Immunohistochemical Detection of Two Neuronal Populations Involved in Two Different Episodes of Animal Cognitive Activity

We developed a method to detect and superimpose neuronal populations involved in two different episodes of activity in the brain of single animal. This method is based on usage of two transcriptional factors with different accumulation curves, c-Fos and pCREB, as the markers. The overlap of neuronal...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-11, Vol.154 (1), p.115-117
Main Authors: Chekhov, S. A., Bezriadnov, D. V., Ivashkina, O. I., Amelchenko, E. M., Anokhin, K. V.
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - physiology
Biomarkers
Biomedical and Life Sciences
Biomedicine
Brain - physiology
CA1 Region, Hippocampal - cytology
CA3 Region, Hippocampal - cytology
Cell Biology
Cognition - physiology
Cyclic AMP Response Element-Binding Protein - genetics
Cyclic AMP Response Element-Binding Protein - metabolism
Immunohistochemistry
Internal Medicine
Laboratory Medicine
Male
Maze Learning - physiology
Memory - physiology
Methods
Mice
Mice, Inbred C57BL
Neurons
Neurons - physiology
Neurophysiology
Pathology
Proto-Oncogene Proteins c-fos - genetics
Proto-Oncogene Proteins c-fos - metabolism
Space Perception - physiology
Transcription, Genetic
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Summary:We developed a method to detect and superimpose neuronal populations involved in two different episodes of activity in the brain of single animal. This method is based on usage of two transcriptional factors with different accumulation curves, c-Fos and pCREB, as the markers. The overlap of neuronal populations involved in performance of spatial and nonspatial tasks in Morris water maze has been shown to occur at “chance” level.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1889-z