Ovarian steroid manipulation of the antidipsogenic and thermogenic responses of rats to central administration of prostaglandin E sub(1)

Intracerebroventricular (icv) injection of prostaglandin E sub(1) (PGE sub(1)) increases arterial pressure, suppresses water intake, and elevates core temperature of rats. This work addressed the effects of daily subcutaneous injection of estradiol, progesterone, or oil vehicle on the antidipsogenic...

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Bibliographic Details
Published in:Behavioral neuroscience 1986-01, Vol.100 (1), p.117-120
Main Authors: Skoog, K M, Muggli, M, Goehler, L, Kenney, N J
Format: Article
Language:English
Subjects:
estradiol
progesterone
prostaglandin E1
rats
ventricles (cerebral)
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Summary:Intracerebroventricular (icv) injection of prostaglandin E sub(1) (PGE sub(1)) increases arterial pressure, suppresses water intake, and elevates core temperature of rats. This work addressed the effects of daily subcutaneous injection of estradiol, progesterone, or oil vehicle on the antidipsogenic and thermogenic response to icv PGE sub(1) of ovariectomized rats. The change of core temperature induced by the PGE treatment was significantly correlated with antidipsogenesis for ovariectomized rats receiving daily oil injections. The linear relation between the thermogenic and antidisogenic actions of the icv PGE sub(1) was abolished by either estradiol or progesterone administration. Thus, although the pressor, antidipsogenic, and thermogenic effects of icv PGE sub(1) tend to occur in concert, they may be differentially affected by ovarian steroid administration, which suggests that the mechanisms underlying these varied effects of icv PGE sub(1) may be independent.
ISSN:0735-7044