Continuous production of lactic acid in a cell recycle reactor

The production of lactic acid from glucose has been demonstrated using a CSTR (continuous stirred-tank reactor) with cell recycle. Studies were conducted with Lactobacillus delbrueckii at a fermentation temperature of 42 degree C and a pH of 6.25. A cell density of 140 g dry weight/L and a volumetri...

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Bibliographic Details
Published in:Applied biochemistry and biotechnology 1985-08, Vol.11 (4), p.317-332
Main Authors: OHLEYER, E, BLANCH, H. W, WILKE, C. R
Format: Article
Language:English
Subjects:
Biological and medical sciences
bioreactors
Biotechnology
Chemical industry. Chemical engineering
continuous culture
fermentation
Fundamental and applied biological sciences. Psychology
glucose
Industrial applications and implications. Economical aspects
lactic acid
Lactobacillus delbrueckii
reviews
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Summary:The production of lactic acid from glucose has been demonstrated using a CSTR (continuous stirred-tank reactor) with cell recycle. Studies were conducted with Lactobacillus delbrueckii at a fermentation temperature of 42 degree C and a pH of 6.25. A cell density of 140 g dry weight/L and a volumetric productivity of 150 g/L multiplied by h, with complete glucose consumption, were obtained. It was not possible to obtain a lactic acid concentration above 60 g/L because of product inhibition. The specific glucose-consumption for cell maintenance was 0.33 g glucose/g cells multiplied by h.
ISSN:0273-2289
1559-0291
DOI:10.1007/bf02798444