Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3-hydroxyalkanoate)

In this paper, a straightforward method to produce poly(3‐hydroxyalkanoate)‐based multicompartment micelles (MCMs) is presented. Thiol‐ene addition is used to graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3‐hydroxyoctanoate‐co‐hydroxyundecenoate) oligomers ba...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2013-02, Vol.34 (4), p.362-368
Main Authors: Babinot, Julien, Renard, Estelle, Le Droumaguet, Benjamin, Guigner, Jean-Michel, Mura, Simona, Nicolas, Julien, Couvreur, Patrick, Langlois, Valérie
Format: Article
Language:English
Subjects:
Alkenes - chemistry
amphiphilic copolymers
Animals
Applied sciences
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - toxicity
Cell Survival - drug effects
Chemical modifications
Chemical reactions and properties
Copolymers
Electron microscopy
Exact sciences and technology
In vitro testing
Light
Mice
Micelles
multicompartment micelles
Nanocomposites
Nanomaterials
Nanostructure
Nanostructures - chemistry
NIH 3T3 Cells
Oligomers
Organic polymers
Physicochemistry of polymers
poly(3-hydroxyalkanoates)
Polyhydroxyalkanoates - chemistry
Polyhydroxyalkanoates - toxicity
Scattering, Radiation
Sulfhydryl Compounds - chemistry
thiol-ene addition
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Summary:In this paper, a straightforward method to produce poly(3‐hydroxyalkanoate)‐based multicompartment micelles (MCMs) is presented. Thiol‐ene addition is used to graft sequentially perfluorooctyl chains and poly(ethylene glycol) oligomers onto poly(3‐hydroxyoctanoate‐co‐hydroxyundecenoate) oligomers backbone. Well‐defined copolymers are obtained as shown by 1H NMR and size‐exclusion chromatography. After nanoprecipitation in water, novel PHA‐based MCMs are evidenced by cryo‐transmission electron microscopy. Moreover, the cytocompatibility of MCMs is demonstrated in vitro via cell viability assay. A simple and straightforward method to produce poly(3‐hydroxyalkanoate)‐based (PHA) multicompartment micelles is presented. Thiol‐ene addition is used to efficiently synthesize perfluorooctyl and poly(ethylene glycol)‐grafted PHA. These copolymers are shown to self‐assemble into multicompartment micelles upon nanoprecipitation in water by cryo‐transmission electron microscopy. Moreover, their in vitro cytocompatibility is investigated.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201200692