Taguchi orthogonal array design for the optimization of hydrogel nanoparticles for the intravenous delivery of small-molecule drugs

In this study, a 16 runs Taguchi method was applied as an experimental design to establish the optimum conditions for hydrogel nanoparticle preparation. Five relevant factors, chitosan (CS) concentration, pentasodium tripolyphosphate (TPP) concentration, CS‐to‐TPP volume ratio, addition time of the...

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Bibliographic Details
Published in:Journal of applied polymer science 2012-12, Vol.126 (5), p.1714-1724
Main Authors: Hamidi, Mehrdad, Azadi, Amir, Ashrafi, Hajar, Rafiei, Pedram, Mohamadi-Samani, Soliman
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Design engineering
Exact sciences and technology
General pharmacology
Hydrogels
Materials science
Mathematical analysis
Mathematical models
Medical sciences
modeling
Nanoparticles
Natural polymers
Optimization
Orthogonal arrays
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Polymers
Reproduction
Starch and polysaccharides
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Summary:In this study, a 16 runs Taguchi method was applied as an experimental design to establish the optimum conditions for hydrogel nanoparticle preparation. Five relevant factors, chitosan (CS) concentration, pentasodium tripolyphosphate (TPP) concentration, CS‐to‐TPP volume ratio, addition time of the TPP solution to the CS solution, and temperature, were selected as the main determinants, and the effects of each factor on the size of the hydrogel nanoparticles were studied at four levels. The statistical analysis revealed that the most important factors contributing to the achievement of minimum particle size were the CS‐to‐TPP volume ratio and the CS concentration. By solving a set of equations derived from the differentiation of the final model, we established the optimum conditions for hydrogel nanoparticle preparation as follows: CS concentration = 0.28% w/v, TPP concentration = 3.17% w/v, TPP/CS = 1 : 8, temperature = 25.66°C, and addition time of the TPP solution to the CS solution = 0.4 min. Also, an analysis of response at the different levels of the factors indicated that there was no remarkable interaction between them. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2012
ISSN:0021-8995
1097-4628
DOI:10.1002/app.36778