A Highly Crystalline Manganese-Doped Iron Oxide Nanocontainer with Predesigned Void Volume and Shape for Theranostic Applications

Hollow Mn‐doped iron oxide nanocontainers, formed by a novel one‐pot synthetic process, fulfill the dual requirements of delivering an effective dose of an anticancer drug to tumor tissue and enabling image‐contrast monitoring of the nanocontainer fate through T2‐weighted magnetic resonance imaging,...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2013-06, Vol.25 (23), p.3202-3208
Main Authors: Phan, Vu Ngoc, Lim, Eun-Kyung, Kim, Taekhoon, Kim, Minsik, Choi, Yuna, Kim, Byeongyoon, Lee, Myounghoon, Oh, Aram, Jin, Juhong, Chae, Youngjoo, Baik, Hionsuck, Suh, Jin-Suck, Haam, Seungjoo, Huh, Yong-Min, Lee, Kwangyeol
Format: Article
Language:English
Subjects:
Animals
anisotropic etching
Antibiotics, Antineoplastic - administration & dosage
Cell Line
Crystal structure
Crystallization
Diagnostic systems
Doxorubicin - administration & dosage
Drug Carriers - chemistry
Ferric Compounds - chemistry
Humans
Hydrogen-Ion Concentration
hydrophobic cavities
Iron oxides
Liver Neoplasms - drug therapy
magnetic resonance imaging
Manganese - chemistry
Mice
Monitoring
Nanocomposites
nanocontainers
Nanomaterials
Nanostructure
Nanostructures - chemistry
Optimization
Particle Size
theranostics
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Summary:Hollow Mn‐doped iron oxide nanocontainers, formed by a novel one‐pot synthetic process, fulfill the dual requirements of delivering an effective dose of an anticancer drug to tumor tissue and enabling image‐contrast monitoring of the nanocontainer fate through T2‐weighted magnetic resonance imaging, thereby determining the optimal balance between diagnostic and therapeutic moieties in an all‐in‐one theranostic nanoplatform.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201300525