Magnetic nanoparticles for a new drug delivery system to control quercetin releasing for cancer chemotherapy

Quercetin belongs to the chemical class of flavonoids and can be found in many common foods, such as apples, nuts, berries, etc. It has been demonstrated that quercetin has a wide array of biological effects that are considered beneficial to health treatment, mainly as anticancer. However, therapeut...

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Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2011-12, Vol.13 (12), p.6545-6553
Main Authors: Barreto, A. C. H., Santiago, V. R., Mazzetto, S. E., Denardin, J. C., Lavín, R., Mele, Giuseppe, Ribeiro, M. E. N. P., Vieira, Icaro G. P., Gonçalves, Tamara, Ricardo, N. M. P. S., Fechine, P. B. A.
Format: Article
Language:English
Subjects:
Biological effects
Characterization and Evaluation of Materials
Chemistry and Materials Science
Flavonoids
Inorganic Chemistry
Lasers
Materials Science
Nanoparticles
Nanotechnology
Optical Devices
Optics
Photonics
Physical Chemistry
Research Paper
Thermal analysis
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Summary:Quercetin belongs to the chemical class of flavonoids and can be found in many common foods, such as apples, nuts, berries, etc. It has been demonstrated that quercetin has a wide array of biological effects that are considered beneficial to health treatment, mainly as anticancer. However, therapeutic applications of quercetin have been restricted to oral administration due to its sparing solubility in water and instability in physiological medium. A drug delivery methodology was proposed in this work to study a new quercetin release system in the form of magnetite–quercetin–copolymer (MQC). These materials were characterized through XRD, TEM, IR, and Thermal analysis. In addition, the magnetization curves and quercetin releasing experiments were performed. It was observed a nanoparticle average diameter of 11.5 and 32.5 nm at Fe 3 O 4 and MQC, respectively. The presence of magnetic nanoparticles in this system offers the promise of targeting specific organs within the body. These results indicate the great potential for future applications of the MQC to be used as a new quercetin release system.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-011-0559-9