Biocompatibility of novel carboxylated graphene oxideaglutamic acid complexes

The biocompatibility improvement of graphene oxide is crucial for biomedical applications. Herein, we propose to prepare carboxylated graphene oxide (GeneOaCOOH) with glutamic acid (Glu) at different pH values. The complexes (GemeOaCOOH/Glu) are characterized by FT-IR, XRD, TG, and Zeta potential. T...

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Bibliographic Details
Published in:Journal of materials science 2013-10, Vol.48 (20), p.7097-7103
Main Authors: Zhou, Ning-Lin, Gu, Hao, Tang, Fei-Fen, Li, Wen-Xiu, Chen, Yuan-Yuan, Yuan, Jiang
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Blood
Carboxylated
Graphene
Hemolysis
Oxides
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Summary:The biocompatibility improvement of graphene oxide is crucial for biomedical applications. Herein, we propose to prepare carboxylated graphene oxide (GeneOaCOOH) with glutamic acid (Glu) at different pH values. The complexes (GemeOaCOOH/Glu) are characterized by FT-IR, XRD, TG, and Zeta potential. The results show that the complexes have close relation with pH value due to the acid-responsive Glu. It is demonstrated that GeneOaCOOH complexes with Glu via amidation reaction in the basic domain. The blood compatibility of GeneOaCOOH/Glu complexes is evaluated by hemolysis and recalcification test. The results show that the plasma recalcification time is prolonged greatly in the whole blood, and the hemolysis rates are less than 5 %. In a word, GeneOaCOOH/Glu complexes are blood compatible at low concentration, which is potential for producing blood-contacting materials.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-013-7523-2