Characteristics of curcumin-loaded poly (lactic acid) nanofibers for wound healing

Curcumin (Cur) is a well-known extract of the root of Curcuma longa L. that has multi biological functions such as anti-oxidation, anti-inflammatory, anti-cancer, and wound healing properties. In the present study, poly (lactic acid) (PLA) nanofibers were used as a carrier for Cur because PLA nanofi...

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Bibliographic Details
Published in:Journal of materials science 2013-10, Vol.48 (20), p.7125-7133
Main Authors: Nguyen, Thuy Thi Thu, Ghosh, Chiranjit, Hwang, Seong-Gu, Tran, Lam Dai, Park, Jun Seo
Format: Article
Language:English
Subjects:
Anticancer properties
Biocompatibility
Biological
Biological products
Blended
Care and treatment
Cells
Characterization and Evaluation of Materials
Chemistry and Materials Science
Classical Mechanics
Cobalt
Collagen
Crystallography and Scattering Methods
Epidermal growth factor
In vivo methods and tests
Inclusions
Lactic acid
Materials Science
Mice
Miscibility
Nanofibers
Olefins
Organic chemistry
Oxidation
Permeability
Polylactic acid
Polymer Sciences
Porosity
Sheet-metal
Skin
Solid Mechanics
Tensile tests
Tissue engineering
Wound healing
Wounds and injuries
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Summary:Curcumin (Cur) is a well-known extract of the root of Curcuma longa L. that has multi biological functions such as anti-oxidation, anti-inflammatory, anti-cancer, and wound healing properties. In the present study, poly (lactic acid) (PLA) nanofibers were used as a carrier for Cur because PLA nanofibers are biocompatible and have a high-specific surface area and high porosity, which can enhance the functional properties of Cur. The chemical and biological characteristics of Cur/PLA blended nanofibers containing varied amounts of Cur were examined. An increase from 0.125 to 6.250 wt% Cur in PLA caused a decrease in the diameters of the nanofibers from 971 ± 274 to 562 ± 177 nm. At Cur concentrations of
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-013-7527-y