Recent methodological and instrumental development in MEKC

The review gives an update about the methodological and instrumental developments in micellar electrokinetic capillary chromatography as a type of CE analytical technique. Here, the last two years development of the technique are particularly presented. Recent approaches to improve sensitivity are d...

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Bibliographic Details
Published in:Electrophoresis 2013-05, Vol.34 (9-10), p.1295-1303
Main Authors: Deeb, Sami El, Dawwas, Hanaa Asad, Gust, Ronald
Format: Article
Language:English
Subjects:
Animals
Capillarity
Charging
Chromatography
Chromatography, Micellar Electrokinetic Capillary - instrumentation
Chromatography, Micellar Electrokinetic Capillary - methods
Computer Simulation
Electrokinetics
Electrophoresis
Equipment Design
Humans
Mass spectrometry
Mathematical analysis
Micellar electrokinetic capillary chromatography / Micelle to solvent stacking / Preconcentration / Theoretical model
Micelles
Models, Chemical
Sensitivity and Specificity
Separation
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Summary:The review gives an update about the methodological and instrumental developments in micellar electrokinetic capillary chromatography as a type of CE analytical technique. Here, the last two years development of the technique are particularly presented. Recent approaches to improve sensitivity are discussed. Newly introduced concentration techniques and experimental methods for verification of the different mechanisms and processes of micellar electrokinetic chromatography analysis are highlighted. A theoretical model to explain changes in separation and electrophoretic mobility order of fully charged analytes are demonstrated. Modern approaches for improving compatibility of micellar electrokinetic capillary chromatography to mass spectrometry are also reported.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.201200574