Effective Column Extraction from Decomposed Tissue in a Suspected Overdose Case Involving Maprotiline and Amitriptyline

This paper describes the use of a Celite 560 column extraction technique in the initial separation of drugs from the contents of the skull of a severely decomposed body. Analysis of the extract obtained resulted in the determination of the presence of amitriptyline, and maprotiline and two of its me...

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Bibliographic Details
Published in:Journal of analytical toxicology 1985-09, Vol.9 (5), p.230-231, Article 230
Main Authors: Fernandez, G.S., Witherington, T.L., Stafford, D.T.
Format: Article
Language:English
Subjects:
Amitriptyline - analysis
Amitriptyline - poisoning
Anthracenes - analysis
Biological and medical sciences
Chromatography, Gas
Drug intoxications. Doping
Female
Humans
Maprotiline - analysis
Maprotiline - poisoning
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Postmortem Changes
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Summary:This paper describes the use of a Celite 560 column extraction technique in the initial separation of drugs from the contents of the skull of a severely decomposed body. Analysis of the extract obtained resulted in the determination of the presence of amitriptyline, and maprotiline and two of its metabolites. As a consequence, the laboratory was able to provide the medical examiner with information concerning an extremely difficult case.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/9.5.230