Methylmercury toxicity in spontaneously hypertensive rats (SHR)

This study was designed to delineate the toxicity of MeHg in animals having high blood pressure using the laboratory model of spontaneously hypertensive rats (SHR). This rodent model was developed for the study of spontaneous hypertension in animals and of essential hypertension in man. This establi...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1986-05, Vol.36 (5), p.668-673
Main Authors: TAMASHIRO, H, ARAKAKI, M, AKAGI, H, HIRAYAMA, K, SMOLENSKY, M. H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - metabolism
Chemical and industrial products toxicology. Toxic occupational diseases
Hypertension - physiopathology
Medical sciences
Metals and various inorganic compounds
Methylmercury Compounds - metabolism
Methylmercury Compounds - toxicity
Rats
Rats, Inbred SHR - physiology
Rats, Inbred Strains - physiology
Time Factors
Tissue Distribution
Toxicology
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Summary:This study was designed to delineate the toxicity of MeHg in animals having high blood pressure using the laboratory model of spontaneously hypertensive rats (SHR). This rodent model was developed for the study of spontaneous hypertension in animals and of essential hypertension in man. This established animal model has been used widely for this purpose. This paper presents the mortality as well as distribution mercury in the tissues of SHR and control rats treated orally with methylmercury chloride (MMC: 5 mg/kg/day) for 10 consecutive days.
ISSN:0007-4861
1432-0800
DOI:10.1007/bf01623567