Differing effects of antiinsulin serum and antiinsulin receptor serum on super(123)I-insulin metabolism in rats

Anesthetized rats were treated with saline, antiinsulin receptor serum, or antiinsulin serum, and the biodistribution of high pressure liquid chromatography-purified super(123)I-Tyr A14-insulin was studied by scintillation scanning. Both insulin antibodies and anti-receptor antibodies alter the dist...

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Bibliographic Details
Published in:The Journal of clinical investigation 1985-01, Vol.75 (5), p.1455-1462
Main Authors: Sodoyez, J-C, Sodoyez-Goffaux, F, von Frenckell, R, de Vos, CJ, Treves, S, Kahn, C R
Format: Article
Language:English
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Summary:Anesthetized rats were treated with saline, antiinsulin receptor serum, or antiinsulin serum, and the biodistribution of high pressure liquid chromatography-purified super(123)I-Tyr A14-insulin was studied by scintillation scanning. Both insulin antibodies and anti-receptor antibodies alter the distribution of insulin, but with very different patterns. The use of super(123)I-insulin and scintillation scanning allows one to study specific alterations in insulin distribution in animal models of insulin-resistant states, and should also be useful in human disease states.
ISSN:0021-9738