A novel method for enhancement of peptide vaccination utilizing T-cell epitopes from conventional vaccines

Highlights ► We designed the vaccine peptide including the T-cell epitope from diphtheria toxoid. ► Pre-immunization of diphtheria vaccine enhanced immunogenicities of the peptide. ► Anti-amyloid beta antibodies were induced by intranasal immunization of the peptide.

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Bibliographic Details
Published in:Vaccine 2013-03, Vol.31 (11), p.1510-1515
Main Authors: Yano, Akira, Miwa, Yoshikatsu, Kanazawa, Yoshito, Ito, Kaori, Makino, Mitsuhiro, Imai, Susumu, Hanada, Nobuhiro, Nisizawa, Tosiki
Format: Article
Language:English
Subjects:
Adjuvants
Allergy and Immunology
Alzheimer's disease
Amyloid beta-Peptides - administration & dosage
Amyloid beta-Peptides - genetics
Amyloid beta-Peptides - immunology
Amyloid-beta peptide
Animals
Antigens
Applied microbiology
Bacterial diseases
Biological and medical sciences
Cells, Cultured
Diphtheria
Diphtheria toxoid
Ent and stomatologic bacterial diseases
Epitopes, B-Lymphocyte - genetics
Epitopes, B-Lymphocyte - immunology
Epitopes, T-Lymphocyte - genetics
Epitopes, T-Lymphocyte - immunology
Experiments
Fundamental and applied biological sciences. Psychology
Human bacterial diseases
Humans
Immunization
Immunotherapy
Infectious diseases
Lymphocytes - immunology
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Microbiology
Peptide vaccine
Peptides
Tetanus
Toxoids - administration & dosage
Toxoids - genetics
Toxoids - immunology
Vaccination - methods
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Subunit - administration & dosage
Vaccines, Subunit - genetics
Vaccines, Subunit - immunology
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - genetics
Vaccines, Synthetic - immunology
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Description
Summary:Highlights ► We designed the vaccine peptide including the T-cell epitope from diphtheria toxoid. ► Pre-immunization of diphtheria vaccine enhanced immunogenicities of the peptide. ► Anti-amyloid beta antibodies were induced by intranasal immunization of the peptide.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.12.083