Intrapartum antibiotic prophylaxis for the prevention of perinatal group B streptococcal disease: Experience in the United States and implications for a potential group B streptococcal vaccine

Highlights ► We reviewed intrapartum prophylaxis impact on newborn group B streptococcal disease. ► US uptake of prenatal screening and intrapartum antibiotics was rapid and widespread. ► The incidence of invasive early-onset GBS disease decreased by more than 80%. ► From 1994 to 2010 over 70,000 ca...

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Bibliographic Details
Published in:Vaccine 2013-08, Vol.31, p.D20-D26
Main Authors: Schrag, Stephanie J, Verani, Jennifer R
Format: Article
Language:English
Subjects:
Allergy and Immunology
ampicillin
Ampicillin - therapeutic use
Anti-Bacterial Agents - therapeutic use
Antibiotic Prophylaxis - methods
clinical trials
disease control
disease incidence
Female
Group B streptococcus
guidelines
Humans
hypersensitivity
Infant, Newborn
Infant, Newborn, Diseases - drug therapy
Infant, Newborn, Diseases - microbiology
Infant, Newborn, Diseases - prevention & control
Infectious Disease Transmission, Vertical - prevention & control
Intrapartum antibiotic prophylaxis
intravenous injection
Maternal immunization
mothers
Neonatal sepsis
neonates
Penicillins - therapeutic use
Pregnancy
Premature Birth
Prenatal Diagnosis
Reproductive Tract Infections - drug therapy
Reproductive Tract Infections - microbiology
risk factors
screening
Streptococcal Infections - drug therapy
Streptococcal Infections - microbiology
Streptococcal Infections - prevention & control
Streptococcal Vaccines
Streptococcus
Streptococcus agalactiae
Streptococcus agalactiae - immunology
therapeutics
United States
vaccines
women
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Summary:Highlights ► We reviewed intrapartum prophylaxis impact on newborn group B streptococcal disease. ► US uptake of prenatal screening and intrapartum antibiotics was rapid and widespread. ► The incidence of invasive early-onset GBS disease decreased by more than 80%. ► From 1994 to 2010 over 70,000 cases of newborn invasive GBS disease were prevented. ► Current prevention limitations might be addressed by a maternal GBS vaccine.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.11.056