Immunological memory and nasopharyngeal carriage in 4-year-old children previously primed and boosted with 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) with or without concomitant prophylactic paracetamol

Highlights ► PHiD-CV immunisation with prophylactic paracetamol (PP) induced immune memory. ► Minor impact of previous PP on antibody persistence up to 3 years (y) post-booster. ► Nasopharyngeal carriage of vaccine serotypes reduced up to 3 y post-PHiD-CV booster. ► Previous PP seemed to have a limi...

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Bibliographic Details
Published in:Vaccine 2013-04, Vol.31 (16), p.2080-2088
Main Authors: Prymula, Roman, Habib, Ahsan, François, Nancy, Borys, Dorota, Schuerman, Lode
Format: Article
Language:English
Subjects:
acetaminophen
Acetaminophen - administration & dosage
Allergy and Immunology
Antibodies
Antibodies, Bacterial - immunology
Antibody persistence
Applied microbiology
Bacterial Proteins - immunology
Bacteriology
Biological and medical sciences
Child, Preschool
children
Female
Fundamental and applied biological sciences. Psychology
Haemophilus influenzae
Haemophilus influenzae - chemistry
Haemophilus influenzae - immunology
Humans
immune response
Immunization, Secondary
immunologic memory
Immunologic Memory - immunology
Immunological memory
Male
Microbiology
Miscellaneous
Nasopharyngeal carriage
Nasopharynx - immunology
Neisseria meningitidis
Pneumococcal Infections - immunology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines - administration & dosage
Pneumococcal Vaccines - adverse effects
Pneumococcal Vaccines - immunology
Prophylactic paracetamol
secondary immunization
serotypes
Streptococcus pneumoniae
tetanus
Vaccination
Vaccine
vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Conjugate - administration & dosage
Vaccines, Conjugate - adverse effects
Vaccines, Conjugate - immunology
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Description
Summary:Highlights ► PHiD-CV immunisation with prophylactic paracetamol (PP) induced immune memory. ► Minor impact of previous PP on antibody persistence up to 3 years (y) post-booster. ► Nasopharyngeal carriage of vaccine serotypes reduced up to 3 y post-PHiD-CV booster. ► Previous PP seemed to have a limited impact on pneumococcal carriage rates. ► PP-altered lower PHiD-CV immunogenicity is probably of limited clinical relevance.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.01.044