A review of the toxicology and pathology of the gastrointestinal tract

The gastrointestinal tract of man and animals shows great specialization in structure and function for its primary role of digestion. There are many species differences in diet, anatomy and metabolism, and its neuroendocrine regulation has evolved into a complex field for investigation. Exposure of...

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Bibliographic Details
Published in:Cell biology and toxicology 2013-10, Vol.29 (5), p.321-338
Main Author: Betton, G. R.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Biochemistry
Biomedical and Life Sciences
Cancer
Carcinogenesis
Carcinogenesis - chemically induced
Cell Biology
Digestive system
Gastric Mucosa - drug effects
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Gastrointestinal Neoplasms - chemically induced
Gastrointestinal Neoplasms - pathology
Gastrointestinal tract
Gastrointestinal Tract - drug effects
Gastrointestinal Tract - metabolism
Gastrointestinal Tract - pathology
Helicobacter Infections - pathology
Humans
Invited Review Article
Life Sciences
Pathogenesis
Pharmacology/Toxicology
Proton Pump Inhibitors - adverse effects
Salivary Glands - drug effects
Salivary Glands - pathology
Salivary Glands - physiopathology
Toxicology
Ulcer - chemically induced
Ulcer - microbiology
Ulcer - pathology
Xenobiotics - adverse effects
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Description
Summary:The gastrointestinal tract of man and animals shows great specialization in structure and function for its primary role of digestion. There are many species differences in diet, anatomy and metabolism, and its neuroendocrine regulation has evolved into a complex field for investigation. Exposure of the tract from oral cavity, stomach, small and large intestine results in a range of toxicities covered by this review. Carcinogenesis of the gastrointestinal tract by a range of agents including pharmaceuticals is also discussed.
ISSN:0742-2091
1573-6822
DOI:10.1007/s10565-013-9257-y