Effect of the steroid molecule structure on the direction of its hydroxylation by the fungus Curvularia lunata

The main and side products of hydroxylation by the C. lunata VKPM F-981 mycelium of fourteen Δ₄-3-ketosteroids of the estrane, androstane, and pregnane series and six of their Δ⁵-3β-hydroxy analogues were identified by H¹PMR spectroscopy and comparison with standard samples. The obtained experimenta...

Full description

Saved in:
Bibliographic Details
Published in:Applied biochemistry and microbiology 2013-07, Vol.49 (4), p.386-394
Main Authors: Andryushina, V. A, Yaderets, V. V, Stytsenko, T. S, Druzhinina, A. V, Voishvillo, N. E
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Curvularia lunata
Fungi
hydroxylation
Life Sciences
Medical Microbiology
Microbiology
Molecules
mycelium
spectroscopy
Steroids
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The main and side products of hydroxylation by the C. lunata VKPM F-981 mycelium of fourteen Δ₄-3-ketosteroids of the estrane, androstane, and pregnane series and six of their Δ⁵-3β-hydroxy analogues were identified by H¹PMR spectroscopy and comparison with standard samples. The obtained experimental data are considered in terms of the triangular model of the enzyme-substrate interaction. The dependence of the direction of hydroxylation of steroid molecules and the orientation of hydroxy groups on the structure of the initial substrate was revealed.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683813040030