A study of the genetic variability of human respiratory syncytial virus in Croatia, 2006-2008

Human respiratory syncytial virus (HRSV) is a common etiological agent of acute lower respiratory tract disease in infants. The molecular epidemiology of HRSV in Croatia over four consecutive seasons (from 2006 to 2008) was investigated. A total of 72 HRSV samples were chosen from 696 screened cases...

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Bibliographic Details
Published in:Journal of medical virology 2012-12, Vol.84 (12), p.1985-1992
Main Authors: Forcic, Dubravko, Ivancic-Jelecki, Jelena, Mlinaric-Galinovic, Gordana, Vojnovic, Gordana, Babic-Erceg, Andrea, Tabain, Irena
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Biological and medical sciences
Child, Preschool
Croatia - epidemiology
Data processing
Epidemiology
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genetic diversity
genetic variability
Genetic Variation
Genotype
Genotype & phenotype
Human respiratory syncytial virus
Human viral diseases
Humans
Infant
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
molecular epidemiology
Molecular Sequence Data
phylogenetic analysis
Phylogenetics
Phylogeny
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus, Human - classification
Respiratory Syncytial Virus, Human - genetics
Respiratory Syncytial Virus, Human - isolation & purification
Seasons
Sequence Alignment
Viral diseases
Virology
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Summary:Human respiratory syncytial virus (HRSV) is a common etiological agent of acute lower respiratory tract disease in infants. The molecular epidemiology of HRSV in Croatia over four consecutive seasons (from 2006 to 2008) was investigated. A total of 72 HRSV samples were chosen from 696 screened cases in a pediatric clinic in Zagreb. Molecular characterization of HRSV revealed the predominance of HRSV group B viruses in the first two epidemic seasons and HRSV group A viruses in the next two seasons. According to the phylogenetic analysis, NA1 and BA9 were the predominant circulating HRSV genotypes detected during the study. Overall, 82.9% of all HRSV A strains belonged to the NA1 genotype. The HRSV B genotype BA9, detected in two consecutive seasons (2006 and 2007), was the predominant circulating HRSV B genotype, accounting for 80.6% of all HRSV B strains. This study provides data on the circulation pattern of HRSV genotypes in Croatia and their molecular characterization. J. Med. Virol. 84:1985–1992, 2012. © 2012 Wiley Periodicals, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.23425