Molecular epidemiology of recent HIV-1 infections in southern Poland

The genetic diversity of human immunodeficiency virus type 1 (HIV‐1) offers an opportunity to track the development of the epidemic across different populations. Viral pol gene fragments from 55 individuals of Polish origin with recent HIV‐1 infection identified in 2008–2010 in four Polish cities we...

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Bibliographic Details
Published in:Journal of medical virology 2012-12, Vol.84 (12), p.1857-1868
Main Authors: Smoleń-Dzirba, Joanna, Rosińska, Magdalena, Kruszyński, Piotr, Bratosiewicz-Wąsik, Jolanta, Janiec, Janusz, Beniowski, Marek, Bociąga-Jasik, Monika, Jabłonowska, Elżbieta, Szetela, Bartosz, Porter, Kholoud, Wąsik, Tomasz J.
Format: Article
Language:English
Subjects:
Adult
Base Sequence
Biological and medical sciences
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genetic diversity
Genetic Variation
Heterosexuality
HIV
HIV Infections - diagnosis
HIV Infections - epidemiology
HIV Infections - transmission
HIV Infections - virology
HIV-1
HIV-1 - classification
HIV-1 - genetics
HIV-1 - pathogenicity
Homosexuality, Male
Human immunodeficiency virus
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Miscellaneous
phylogenetic analysis
Phylogeny
pol gene
pol Gene Products, Human Immunodeficiency Virus - genetics
Poland - epidemiology
RNA, Viral - analysis
RNA, Viral - genetics
Statistics, Nonparametric
transmission
Viral diseases
Virology
Young Adult
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Summary:The genetic diversity of human immunodeficiency virus type 1 (HIV‐1) offers an opportunity to track the development of the epidemic across different populations. Viral pol gene fragments from 55 individuals of Polish origin with recent HIV‐1 infection identified in 2008–2010 in four Polish cities were analyzed. Viral sequences were compared with sequences from 100 individuals (reference group) infected before 2004. Viral spread among groups with different HIV transmission categories was compared using a phylogenetic approach. The majority of sequences from individuals with recent infection were subtype B (93%) within which four transmission clusters (18% of samples) were detected. Samples from men infected through sex between men and from persons infected through injecting drugs were broadly separated (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.23395