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Contribution of 4–1 BB L on radioresistant cells in providing survival signals through 4–1 BB expressed on CD 8+ memory T cells in the bone marrow
The persistence of memory lymphocytes is a critical feature of adaptive immunity. The TNF family ligand 4–1 BBL supports the antigen‐independent survival of CD 8+ memory T cells. Here, we show that mice lacking 4–1 BB only on αβ T cells show a similar defect in CD 8+ T ‐cell recall responses, as pre...
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Published in: | European journal of immunology 2012-11, Vol.42 (11), p.2861-2874 |
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container_end_page | 2874 |
container_issue | 11 |
container_start_page | 2861 |
container_title | European journal of immunology |
container_volume | 42 |
creator | Lin, Gloria H. Y. Edele, Fanny Mbanwi, Achire N. Wortzman, Michael E. Snell, Laura M. Vidric, Mariana Roth, Katrin Hauser, Anja E. Watts, Tania H. |
description | The persistence of memory lymphocytes is a critical feature of adaptive immunity. The
TNF
family ligand 4–1
BBL
supports the antigen‐independent survival of
CD
8+ memory
T
cells. Here, we show that mice lacking 4–1
BB
only on αβ
T
cells show a similar defect in
CD
8+
T
‐cell recall responses, as previously shown in 4–1
BBL
‐deficient mice. We show that 4–1
BB
is selectively expressed on
BM CD
8+ but not
CD
4
+
memory
T
cells of unimmunized mice. Its ligand, 4–1
BBL
, is found on
VCAM
‐1+ stromal cells,
CD
11c+ cells, and a
G
r1
lo
myeloid population in unimmunized mice. Adoptive transfer of in vitro generated memory
T
cells into mice lacking 4–1
BBL
only on radioresistant cells recapitulates the defect in
CD
8
+
T
‐cell survival seen in the complete knockout mice, with smaller effects of 4–1
BBL
on hematopoietic cells. In BM, adoptively transferred
D
s
R
ed
CD
8+ memory
T
cells are most often found in proximity to
VCAM
‐1+ cells or
G
r1+ cells, followed by
B
220+ cells and to a much lesser extent near
CD
11c+ cells. Thus, a
VCAM
‐1+
CD
45
−
stromal cell is a plausible candidate for the radioresistant cell that provides 4–1
BBL
to
CD
8+ memory
T
cells in the
BM
. |
doi_str_mv | 10.1002/eji.201242503 |
format | article |
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TNF
family ligand 4–1
BBL
supports the antigen‐independent survival of
CD
8+ memory
T
cells. Here, we show that mice lacking 4–1
BB
only on αβ
T
cells show a similar defect in
CD
8+
T
‐cell recall responses, as previously shown in 4–1
BBL
‐deficient mice. We show that 4–1
BB
is selectively expressed on
BM CD
8+ but not
CD
4
+
memory
T
cells of unimmunized mice. Its ligand, 4–1
BBL
, is found on
VCAM
‐1+ stromal cells,
CD
11c+ cells, and a
G
r1
lo
myeloid population in unimmunized mice. Adoptive transfer of in vitro generated memory
T
cells into mice lacking 4–1
BBL
only on radioresistant cells recapitulates the defect in
CD
8
+
T
‐cell survival seen in the complete knockout mice, with smaller effects of 4–1
BBL
on hematopoietic cells. In BM, adoptively transferred
D
s
R
ed
CD
8+ memory
T
cells are most often found in proximity to
VCAM
‐1+ cells or
G
r1+ cells, followed by
B
220+ cells and to a much lesser extent near
CD
11c+ cells. Thus, a
VCAM
‐1+
CD
45
−
stromal cell is a plausible candidate for the radioresistant cell that provides 4–1
BBL
to
CD
8+ memory
T
cells in the
BM
.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.201242503</identifier><language>eng</language><ispartof>European journal of immunology, 2012-11, Vol.42 (11), p.2861-2874</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1159-35732216af8d786cf5d28c731f44f6563b51bb6824fd306d5287526f8f644db23</citedby><cites>FETCH-LOGICAL-c1159-35732216af8d786cf5d28c731f44f6563b51bb6824fd306d5287526f8f644db23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Lin, Gloria H. Y.</creatorcontrib><creatorcontrib>Edele, Fanny</creatorcontrib><creatorcontrib>Mbanwi, Achire N.</creatorcontrib><creatorcontrib>Wortzman, Michael E.</creatorcontrib><creatorcontrib>Snell, Laura M.</creatorcontrib><creatorcontrib>Vidric, Mariana</creatorcontrib><creatorcontrib>Roth, Katrin</creatorcontrib><creatorcontrib>Hauser, Anja E.</creatorcontrib><creatorcontrib>Watts, Tania H.</creatorcontrib><title>Contribution of 4–1 BB L on radioresistant cells in providing survival signals through 4–1 BB expressed on CD 8+ memory T cells in the bone marrow</title><title>European journal of immunology</title><description>The persistence of memory lymphocytes is a critical feature of adaptive immunity. The
TNF
family ligand 4–1
BBL
supports the antigen‐independent survival of
CD
8+ memory
T
cells. Here, we show that mice lacking 4–1
BB
only on αβ
T
cells show a similar defect in
CD
8+
T
‐cell recall responses, as previously shown in 4–1
BBL
‐deficient mice. We show that 4–1
BB
is selectively expressed on
BM CD
8+ but not
CD
4
+
memory
T
cells of unimmunized mice. Its ligand, 4–1
BBL
, is found on
VCAM
‐1+ stromal cells,
CD
11c+ cells, and a
G
r1
lo
myeloid population in unimmunized mice. Adoptive transfer of in vitro generated memory
T
cells into mice lacking 4–1
BBL
only on radioresistant cells recapitulates the defect in
CD
8
+
T
‐cell survival seen in the complete knockout mice, with smaller effects of 4–1
BBL
on hematopoietic cells. In BM, adoptively transferred
D
s
R
ed
CD
8+ memory
T
cells are most often found in proximity to
VCAM
‐1+ cells or
G
r1+ cells, followed by
B
220+ cells and to a much lesser extent near
CD
11c+ cells. Thus, a
VCAM
‐1+
CD
45
−
stromal cell is a plausible candidate for the radioresistant cell that provides 4–1
BBL
to
CD
8+ memory
T
cells in the
BM
.</description><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpFkMtKAzEUhoMoWKtL91kKMjX3ySxtvULBTV0PM5OkTekkNZmpduc7CD6gT2JKxa4OnPPz8Z8PgEuMRhghcqOXdkQQJoxwRI_AAHOCM4YZPgYDhDDLSCHRKTiLcYkQKgQvBuB74l0XbN131jvoDWQ_n18YjsdwCtMiVMr6oKONXeU62OjVKkLr4Dr4jVXWzWHsw8ZuqhWMdu6qdO0WwffzxQGkP9aJELXaASd3UF7DVrc-bOHsAOwWGtbeadhWIfj3c3BiEkxf_M0heH24n02esunL4_Pkdpo1GPMiozynhGBRGalyKRrDFZFNTrFhzAguaM1xXQtJmFEUCcWJzDkRRhrBmKoJHYKrPTc99Nbr2JWtjbtSldO-jyVmjNJccl6kaLaPNsHHGLQp18GmttsSo3Lnv0z-y3__9Becanlp</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Lin, Gloria H. Y.</creator><creator>Edele, Fanny</creator><creator>Mbanwi, Achire N.</creator><creator>Wortzman, Michael E.</creator><creator>Snell, Laura M.</creator><creator>Vidric, Mariana</creator><creator>Roth, Katrin</creator><creator>Hauser, Anja E.</creator><creator>Watts, Tania H.</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201211</creationdate><title>Contribution of 4–1 BB L on radioresistant cells in providing survival signals through 4–1 BB expressed on CD 8+ memory T cells in the bone marrow</title><author>Lin, Gloria H. Y. ; Edele, Fanny ; Mbanwi, Achire N. ; Wortzman, Michael E. ; Snell, Laura M. ; Vidric, Mariana ; Roth, Katrin ; Hauser, Anja E. ; Watts, Tania H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1159-35732216af8d786cf5d28c731f44f6563b51bb6824fd306d5287526f8f644db23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Gloria H. Y.</creatorcontrib><creatorcontrib>Edele, Fanny</creatorcontrib><creatorcontrib>Mbanwi, Achire N.</creatorcontrib><creatorcontrib>Wortzman, Michael E.</creatorcontrib><creatorcontrib>Snell, Laura M.</creatorcontrib><creatorcontrib>Vidric, Mariana</creatorcontrib><creatorcontrib>Roth, Katrin</creatorcontrib><creatorcontrib>Hauser, Anja E.</creatorcontrib><creatorcontrib>Watts, Tania H.</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Gloria H. Y.</au><au>Edele, Fanny</au><au>Mbanwi, Achire N.</au><au>Wortzman, Michael E.</au><au>Snell, Laura M.</au><au>Vidric, Mariana</au><au>Roth, Katrin</au><au>Hauser, Anja E.</au><au>Watts, Tania H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of 4–1 BB L on radioresistant cells in providing survival signals through 4–1 BB expressed on CD 8+ memory T cells in the bone marrow</atitle><jtitle>European journal of immunology</jtitle><date>2012-11</date><risdate>2012</risdate><volume>42</volume><issue>11</issue><spage>2861</spage><epage>2874</epage><pages>2861-2874</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>The persistence of memory lymphocytes is a critical feature of adaptive immunity. The
TNF
family ligand 4–1
BBL
supports the antigen‐independent survival of
CD
8+ memory
T
cells. Here, we show that mice lacking 4–1
BB
only on αβ
T
cells show a similar defect in
CD
8+
T
‐cell recall responses, as previously shown in 4–1
BBL
‐deficient mice. We show that 4–1
BB
is selectively expressed on
BM CD
8+ but not
CD
4
+
memory
T
cells of unimmunized mice. Its ligand, 4–1
BBL
, is found on
VCAM
‐1+ stromal cells,
CD
11c+ cells, and a
G
r1
lo
myeloid population in unimmunized mice. Adoptive transfer of in vitro generated memory
T
cells into mice lacking 4–1
BBL
only on radioresistant cells recapitulates the defect in
CD
8
+
T
‐cell survival seen in the complete knockout mice, with smaller effects of 4–1
BBL
on hematopoietic cells. In BM, adoptively transferred
D
s
R
ed
CD
8+ memory
T
cells are most often found in proximity to
VCAM
‐1+ cells or
G
r1+ cells, followed by
B
220+ cells and to a much lesser extent near
CD
11c+ cells. Thus, a
VCAM
‐1+
CD
45
−
stromal cell is a plausible candidate for the radioresistant cell that provides 4–1
BBL
to
CD
8+ memory
T
cells in the
BM
.</abstract><doi>10.1002/eji.201242503</doi><tpages>14</tpages></addata></record> |
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language | eng |
recordid | cdi_proquest_miscellaneous_1443378559 |
source | Wiley-Blackwell Read & Publish Collection |
title | Contribution of 4–1 BB L on radioresistant cells in providing survival signals through 4–1 BB expressed on CD 8+ memory T cells in the bone marrow |
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