Immune functional impacts of oyster peptide-based enteral nutrition formula (OPENF) on mice: a pilot study

Oyster peptides were produced from Crassostrea hongkongensis and used as a new protein source for the preparation of an oyster peptide-based enteral nutrition formula (OPENF). Reserpineinduced malabsorption mice and cyclophosphamide-induced immunosuppression mice were used in this study. OPENF powde...

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Bibliographic Details
Published in:Chinese journal of oceanology and limnology 2013-07, Vol.31 (4), p.813-820
Main Authors: Cai, Bingna, Pan, Jianyu, Wu, Yuantao, Wan, Peng, Sun, Huili
Format: Article
Language:English
Subjects:
Biology
Carbohydrates
Cell proliferation
Crassostrea
Crassostrea hongkongensis
Cyclophosphamide
Earth and Environmental Science
Earth Sciences
enteral feeding
Enteral nutrition
Immunosuppression
Intestinal absorption
lymphocyte proliferation
Lymphocytes
Malabsorption
Marine
Marine molluscs
mice
Natural killer cells
Nutrition
Oceanography
Oysters
Peptides
Physiological functions
Proliferation
Proteins
Rodents
Spleen
water solubility
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Summary:Oyster peptides were produced from Crassostrea hongkongensis and used as a new protein source for the preparation of an oyster peptide-based enteral nutrition formula (OPENF). Reserpineinduced malabsorption mice and cyclophosphamide-induced immunosuppression mice were used in this study. OPENF powder is light yellow green and has a protein-fat-carbohydrate ratio of 16:9:75 with good solubility in water. A pilot study investigating immune functional impacts of the OPENF on mice show that the OPENF enhanced spleen lymphocyte proliferation and the activity of natural killer (NK) cells in BALB/c mice. Furthermore, OPENF can improve intestinal absorption, increase food utilization ratio, and maintain the normal physiological function of mice. These results suggest that oyster peptides could serve as a new protein source for use in enteral nutrition formula, but more importantly, also indicate that OPENF has an immunostimulating effect in mice.
ISSN:0254-4059
2096-5508
1993-5005
2523-3521
DOI:10.1007/s00343-013-2311-z