Effects of sevoflurane and desflurane on oxidative stress during general anesthesia for elective cesarean section

Summary Background Anesthetic agents might considerably influence maternal-fetal oxidative stress and antioxidants during cesarean section (CS). The aim of this study was to investigate the effects of desflurane and sevoflurane on oxidative stress parameters both in mothers and newborns undergoing e...

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Bibliographic Details
Published in:Wiener Klinische Wochenschrift 2013-08, Vol.125 (15-16), p.467-473
Main Authors: Yalcin, Saban, Aydoğan, Harun, Yuce, Hasan Husnu, Kucuk, Ahmet, Karahan, Mahmut Alp, Vural, Mehmet, Camuzcuoğlu, Aysun, Aksoy, Nurten
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthetics, General - pharmacology
Anesthetics, Inhalation
Cesarean Section
Elective Surgical Procedures
Endocrinology
Female
Fetal Blood - metabolism
Gastroenterology
Humans
Internal Medicine
Isoflurane - analogs & derivatives
Isoflurane - pharmacology
Male
Medicine
Medicine & Public Health
Methyl Ethers - pharmacology
Original Article
Oxidative Stress - drug effects
Oxidative Stress - physiology
Pneumology/Respiratory System
Pregnancy - blood
Reactive Oxygen Species - blood
Reproducibility of Results
Sensitivity and Specificity
Young Adult
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Summary:Summary Background Anesthetic agents might considerably influence maternal-fetal oxidative stress and antioxidants during cesarean section (CS). The aim of this study was to investigate the effects of desflurane and sevoflurane on oxidative stress parameters both in mothers and newborns undergoing elective CS. Materials and methods Eighty ASA physical status I–II, term parturients undergoing elective CS under general anesthesia were randomized to desflurane (Group D) and sevoflurane (Group S) groups. Blood samples were collected from mothers before operation and postoperatively and umbilical artery samples were obtained at delivery. Total oxidant status (TOS), total antioxidant capacity (TAC) status, lipid hydroperoxide (LOOH), and free sulfhydryl (–SH) levels were measured and oxidative stress index was calculated. Secondary outcomes included maternal hemodynamics. Results Preoperative LOOH, TOS, OSI, TAC, and –SH levels were similar among groups. Postoperative maternal serum LOOH, TOS, and OSI levels were significantly increased in Group D compared to Group S ( p  = 0.003, p  = 0.005, p  = 0.04; respectively). Postoperative umbilical artery LOOH, TOS, OSI levels were also significantly increased in Group D compared to Group S ( p  = 0.04, p  = 0.02, p  = 0.01; respectively). Postoperative TOS ( p  = 0.001,
ISSN:0043-5325
1613-7671
DOI:10.1007/s00508-013-0397-0