Drug-related nail disease

Abstract Drug-induced nail abnormalities can present with a wide variety of clinical manifestations that are often dose-related and that disappear after drug withdrawal. Some nail changes are asymptomatic and only cause cosmetic problems, whereas others cause pain and discomfort and impair manual ac...

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Bibliographic Details
Published in:Clinics in dermatology 2013-09, Vol.31 (5), p.618-626
Main Authors: Piraccini, Bianca Maria, MD, PhD, Alessandrini, Aurora, MD
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Dermatology
Drug Eruptions - etiology
Fingers
Granuloma, Pyogenic - chemically induced
Hemorrhage - chemically induced
Humans
Hyperpigmentation - chemically induced
Hypopigmentation - chemically induced
Nail Diseases - chemically induced
Onycholysis - chemically induced
Paronychia - chemically induced
Protein Kinase Inhibitors - adverse effects
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Summary:Abstract Drug-induced nail abnormalities can present with a wide variety of clinical manifestations that are often dose-related and that disappear after drug withdrawal. Some nail changes are asymptomatic and only cause cosmetic problems, whereas others cause pain and discomfort and impair manual activities or deambulation. New side effects have been recently observed with different groups of anticancer agents. These include painful onycholysis and subungual abscesses caused by taxanes and anthracyclines (eg, doxorubicin) in addition to ingrown nails, paronychia, and pyogenic granuloma associated with the use of tyrosine kinase inhibitors of the epidermal growth factor receptor (eg, erlotinib, gefitinib).
ISSN:0738-081X
1879-1131
DOI:10.1016/j.clindermatol.2013.06.013