Preventive effects of polysaccharides from Liriope spicata var. prolifera on diabetic nephropathy in rats

This study was undertaken to investigate preventive effects of polysaccharides (LSP) from Liriope spicata var. prolifera on diabetic nephropathy in rats, which were induced by high fat-fed and low-dose streptozotocin (STZ). The levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c...

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Bibliographic Details
Published in:International journal of biological macromolecules 2013-10, Vol.61, p.114-120
Main Authors: Xiao, Zuo-qi, Wang, Yong-long, Yue, Yao-dong, Zhang, Yu-tang, Chen, Cui-ping, Wan, Luo-sheng, Deng, Bin, Liu, Zhao-xia, Chen, Jia-chun
Format: Article
Language:English
Subjects:
advanced glycation end products
animal disease models
Animals
Antioxidants - metabolism
Blood Glucose
Carbohydrates - chemistry
Diabetes Mellitus, Experimental
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - pathology
Diabetic nephropathy
fasting
Fasting - blood
glucose tolerance
Glucose Tolerance Test
Glycated Hemoglobin A - metabolism
Glycation End Products, Advanced - metabolism
glycosylation
hemoglobin
Hyperglycemic
hyperlipidemia
Insulin - blood
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Kidney - physiopathology
kidneys
Lipids - blood
Liriope Plant - chemistry
Liriope spicata
Liriope spicata var. prolifera
Male
Molecular Weight
Monosaccharides - chemistry
oxidative stress
Plant Extracts - chemistry
Plant Extracts - pharmacology
Polysaccharide
polysaccharides
Polysaccharides - chemistry
Polysaccharides - pharmacology
Rats
Receptor for Advanced Glycation End Products
Receptors, Immunologic - metabolism
renal function
streptozotocin
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Summary:This study was undertaken to investigate preventive effects of polysaccharides (LSP) from Liriope spicata var. prolifera on diabetic nephropathy in rats, which were induced by high fat-fed and low-dose streptozotocin (STZ). The levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in diabetic rats were significantly decreased after treated with LSP for 28 days. Additional, the glucose tolerance of diabetes rats showed improvement after administration of LSP. The results also indicated that LSP were able to normalize hyperlipidemia, ameliorate oxidative stress, improve renal function parameters, inhibit the structural damages of kidney tissue and down-regulate the system of advanced glycation end products – receptor for advanced glycation end products (AGE-RAGE). In conclusion, LSP had potential preventive effects on diabetic nephropathy in diabetic rats.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2013.06.047