Relationship between knee alignment and T1ρ values of articular cartilage and menisci in patients with knee osteoarthritis

• Published in: European journal of radiology 2013-11, Vol.82 (11), p.1946-1952
• Main Authors: Wang, Ligong, Vieira, Renata La Rocca, Rybak, Leon D., Babb, James S., Chang, Gregory, Krasnokutsky, Svetlana, Abramson, Steven, Regatte, Ravinder
• Format: Article
• Language: English
• Subjects: Aged; Algorithms; Cartilage, Articular - pathology; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Knee alignment; Knee joint; Knee Joint - pathology; Magnetic Resonance Imaging - methods; Male; Menisci, Tibial - pathology; Meniscus; Middle Aged; MRI; Osteoarthritis; Osteoarthritis, Knee - pathology; Reproducibility of Results; Sensitivity and Specificity
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2013.05.010

To assess the relationship between knee alignment and subregional T1ρ values of the femorotibial cartilage and menisci in patients with mild (Kellgren–Lawrence grade 1) to moderate (KL3) osteoarthritis (OA) at 3T. 26 subjects with a clinical diagnosis of KL1-3 OA were included and subdivided into three subgroups: varus, valgus, and neutral. All subjects were evaluated on a 3T MR scanner. Mann–Whitney and Wilcoxon signed rank tests were performed to determine any statistically significant differences in subregional T1ρ values of femorotibial cartilage and menisci among the three subgroups of KL1-3 OA patients. Medial femoral anterior cartilage subregion in varus group had significantly higher (p