Long-term Changes in Leptin, Chemerin and Ghrelin Levels Following Different Bariatric Surgery Procedures: Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

Background Different studies have evaluated changes in adipo/cytokine levels after bariatric surgery and have given conflicting results. The adipo/cytokines, leptin and chemerin, and the orexigenic hormone, ghrelin, have been shown to play a role in the regulation of metabolism and appetite. The aim...

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Bibliographic Details
Published in:Obesity surgery 2013-11, Vol.23 (11), p.1790-1798
Main Authors: Terra, Ximena, Auguet, Teresa, Guiu-Jurado, Esther, Berlanga, Alba, Orellana-Gavaldà, Josep Maria, Hernández, Mercè, Sabench, Fàtima, Porras, Jose Antonio, Llutart, Jordi, Martinez, Salomé, Aguilar, Carmen, Del Castillo, Daniel, Richart, Cristóbal
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Blood Glucose - metabolism
Chemokines - blood
Fasting - metabolism
Female
Gastrectomy - methods
Gastric Bypass
Gastrointestinal surgery
Ghrelin - blood
Humans
Insulin Resistance
Intercellular Signaling Peptides and Proteins
Laparoscopy
Leptin - blood
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Obesity
Obesity, Morbid - blood
Obesity, Morbid - epidemiology
Obesity, Morbid - surgery
Original Contributions
Postoperative Period
Spain - epidemiology
Surgery
Surgical techniques
Time Factors
Treatment Outcome
Weight control
Weight Loss
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Summary:Background Different studies have evaluated changes in adipo/cytokine levels after bariatric surgery and have given conflicting results. The adipo/cytokines, leptin and chemerin, and the orexigenic hormone, ghrelin, have been shown to play a role in the regulation of metabolism and appetite. The aims of our study were to test the levels of these molecules after bariatric surgery and to compare the results between Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy. Methods We analysed circulating levels of chemerin, ghrelin and leptin in 30 morbidly obese women (body mass index of >40 kg/m 2 ). Subjects were studied at three time points: baseline (before the surgery started), and after 6 and 12 months. Results After surgery, chemerin (baseline, 95.03 ± 23.79; after 12 months, 76.80 ± 21.51; p  = 0.034) and leptin levels (baseline, 248.17 ± 89.16; after 12 months, 63.85 ± 33.48; p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-013-1033-9