Generalized periodic epileptiform discharges in critically ill children: Clinical features, and outcome

Highlights • GPEDs are often associated with encephalitis and/or status epilepticus secondary to the other causes. • GPEDs can be seen during the course of SE treatment and resolved by the additional use of anticonvulsant medications. • Seizure recurrence was noted in more than 50% of patients follo...

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Bibliographic Details
Published in:Epilepsy research 2013-10, Vol.106 (3), p.378-385
Main Authors: Akman, Cigdem I, Abou Khaled, Karine J, Segal, Eric, Micic, Vesna, Riviello, James J
Format: Article
Language:English
Subjects:
Adolescent
Anticonvulsants - administration & dosage
Anticonvulsants - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Children
Continuous EEG monitoring
Critical Illness
Critically ill
Disability Evaluation
Electroencephalography
Epilepsy, Generalized - mortality
Epilepsy, Generalized - physiopathology
Female
Generalized periodic epileptiform discharges
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hospital Mortality
Humans
Hypoxia-Ischemia, Brain - etiology
Hypoxia-Ischemia, Brain - mortality
Image Processing, Computer-Assisted
Infusions, Intravenous
Intensive Care Units
Magnetic Resonance Imaging
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neuroimaging
Neurology
Retrospective Studies
Seizures - drug therapy
Seizures - epidemiology
Seizures - etiology
Status Epilepticus - drug therapy
Status Epilepticus - etiology
Treatment Outcome
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Summary:Highlights • GPEDs are often associated with encephalitis and/or status epilepticus secondary to the other causes. • GPEDs can be seen during the course of SE treatment and resolved by the additional use of anticonvulsant medications. • Seizure recurrence was noted in more than 50% of patients following the emergence of GPEDs on EEG. • One fourth of children with GPEDs had fatal outcome, and remaining had mild to moderate disability.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2013.06.019