Nodular heterotopia and absence seizures: fMRI evidence that they may be connected

Highlights • Two patients were identified with absence seizures (AS). • Subjects had co-existent and peri-ventricular nodular heterotopia (PNH). • EEG fMRI was used to explore the potential association between PNH and AS. • The PNH displayed connectivity to the typical absence network. • This study...

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Bibliographic Details
Published in:Epilepsy research 2013-10, Vol.106 (3), p.451-455
Main Authors: Carney, Patrick W, Masterton, Richard A.J, Gill, Deepak, Jackson, Graeme D
Format: Article
Language:English
Subjects:
Absence seizures
Biological and medical sciences
Child
Cohort Studies
EEG
Electroencephalography
Epilepsy, Absence - complications
Epilepsy, Absence - pathology
Epilepsy, Generalized - complications
Epilepsy, Generalized - pathology
Evoked Potentials
fMRI
Functional neuroimaging
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medical sciences
Myoclonic Epilepsy, Juvenile - complications
Myoclonic Epilepsy, Juvenile - pathology
Neostriatum - pathology
Nervous system (semeiology, syndromes)
Neurology
Nodular heterotopia
Parietal Lobe - pathology
Periventricular Nodular Heterotopia - complications
Periventricular Nodular Heterotopia - pathology
Seizures - complications
Seizures - pathology
Thalamus - pathology
Young Adult
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Summary:Highlights • Two patients were identified with absence seizures (AS). • Subjects had co-existent and peri-ventricular nodular heterotopia (PNH). • EEG fMRI was used to explore the potential association between PNH and AS. • The PNH displayed connectivity to the typical absence network. • This study demonstrates that fMRI may be used to understand complex networks.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2013.07.005