Synthesis and antitumor activity of a series of osmium(VI) nitrido complexes bearing quinolinolato ligands

A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os(VI)≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer dr...

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Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (85), p.9980-9982
Main Authors: Tang, Quan, Ni, Wen-Xiu, Leung, Chi-Fai, Man, Wai-Lun, Lau, Kenneth King-Kwan, Liang, Yimin, Lam, Yun-Wah, Wong, Wai-Yeung, Peng, Shie-Ming, Liu, Gui-Jian, Lau, Tai-Chu
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Cell Proliferation - drug effects
Cell Survival - drug effects
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Ferric Compounds - chemistry
Flow Cytometry
Hep G2 Cells
Humans
Inhibitory Concentration 50
Ligands
Molecular Structure
Osmium - chemistry
Osmium - pharmacology
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Summary:A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os(VI)≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc42250j