Ovariectomy Causes Overexpression of Renal Na+,K+-ATPase and Sodium-Sensitive Hypertension in Adult Wistar Rats

We investigated the effect of ovariectomy(oVx) on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated Na+,K+-ATPase α1 subunit (t-d-NKA) in normotensive Wistar rats under a normal sodium (NS, 0.24%) or high sodium (HS, 1%) intake versus intact female (IF). On NS inta...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2013-01, Vol.35 (7), p.475-483
Main Authors: Di Ciano, Luis A, Azurmendi, Pablo J, Toledo, Jorge E, Oddo, Elisabet M, Zotta, Elsa, Ochoa, Federico, Arrizurieta, Elvira E, Ibarra, Fernando R.
Format: Article
Language:English
Subjects:
Animals
ATPase
Blood Pressure
Female
female hormones
Hypertension - enzymology
Hypertension - etiology
Hypertension - physiopathology
Kidney - enzymology
Loop of Henle - enzymology
mTAL
Natriuresis
ovariectomy
Ovariectomy - adverse effects
Ovary - physiology
phospho state
Rats
Rats, Wistar
renal Na
Renal Plasma Flow
sodium excretion
Sodium, Dietary - administration & dosage
Sodium-Potassium-Exchanging ATPase - metabolism
sodium-sensitive hypertension
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Summary:We investigated the effect of ovariectomy(oVx) on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated Na+,K+-ATPase α1 subunit (t-d-NKA) in normotensive Wistar rats under a normal sodium (NS, 0.24%) or high sodium (HS, 1%) intake versus intact female (IF). On NS intake, t-d-NKA was higher in oVx rats and overexpressed in the thick ascending limbs (P < .01 vs. IF) and renal plasma flow was increased. On HS intake, oVx rats maintained a greater dephosphorylated NKA, excreted less sodium, and developed arterial hypertension (134 ± 4 vs. IF 112 ± 5 mm Hg, P < .05). Sodium load caused salt-sensitive hypertension in oVx Wistar rats.
ISSN:1064-1963
1525-6006
DOI:10.3109/10641963.2012.758273