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A study of the effects of sodium halides on the performance of air-jet and vibrating-mesh nebulizers

The influence of sodium halide electrolytes on aerosols generated from the Aeroneb Pro vibrating mesh nebulizer and the Sidestream air-jet nebulizer has been evaluated. Fluids with a range of concentrations of Na halides (i.e. NaF, NaCl, NaBr and NaI) were used as nebulizer solutions and their effec...

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Published in:International journal of pharmaceutics 2013-11, Vol.456 (2), p.520-527
Main Authors: Najlah, Mohammad, Vali, Asma, Taylor, Michael, Arafat, Basel T., Ahmed, Waqar, Phoenix, David A., Taylor, Kevin M.G., Elhissi, Abdelbary
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container_title International journal of pharmaceutics
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creator Najlah, Mohammad
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description The influence of sodium halide electrolytes on aerosols generated from the Aeroneb Pro vibrating mesh nebulizer and the Sidestream air-jet nebulizer has been evaluated. Fluids with a range of concentrations of Na halides (i.e. NaF, NaCl, NaBr and NaI) were used as nebulizer solutions and their effect on aerosol properties such as total aerosol output, fine particle fraction (FPF), volume median diameter (VMD) and predicted regional airway deposition were investigated. For both nebulizers, the inclusion of electrolyte significantly enhanced the aerosol properties compared with HPLC grade (deionized) water. Aerosol output, FPF and aerosol fraction less than 2.15μm were directly proportional to electrolyte concentration. Furthermore, the proportion of aerosols that are likely to deposit in the oropharyngeal region, and the VMD of the droplets were inversely related to the electrolyte concentration for both nebulizers. In general, the inclusion of electrolytes had a greater impact on the aerosol properties of the vibrating-mesh nebulizer. In the Aeroneb Pro, NaI 2.0% (w/v) was the optimum solution as it generated the highest aerosol output, FPF and output fraction below 2.15μm with the lowest VMD and minimal predicted oropharyngeal deposition. This was attributed to the polarizing ability of iodide ions present in the largest quantity at the air–water interface. This study has shown that the Aeroneb Pro vibrating-mesh device demonstrated greatly enhanced aerosol properties when halides were included in the nebulizer solutions.
doi_str_mv 10.1016/j.ijpharm.2013.08.023
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subjects Administration, Inhalation
Aerosol
aerosols
Aerosols - administration & dosage
Aerosols - chemistry
atomizers
droplets
Electrolyte
Electrolytes
Halide
high performance liquid chromatography
iodides
ions
Nebulizer
Nebulizers and Vaporizers
Polarizing ability
sodium
Sodium - administration & dosage
Sodium - chemistry
sodium chloride
sodium fluoride
Surface tension
title A study of the effects of sodium halides on the performance of air-jet and vibrating-mesh nebulizers
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