Analysis of Drugs Illegally Added into Chinese Traditional Patent Medicine Using Surface-enhanced Raman Scattering

Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydr...

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Bibliographic Details
Published in:Analytical Sciences 2013/10/10, Vol.29(10), pp.985-990
Main Authors: ZHANG, Yan, HUANG, Xiaoyan, LIU, Wenfang, CHENG, Zeneng, CHEN, Chuanpin, YIN, Lihui
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chinese traditional patent medicines
Counterfeit Drugs - analysis
illegal additives
Medicine, Chinese Traditional
Spectrum Analysis, Raman
Surface Properties
Surface-enhanced Raman spectroscopy
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Summary:Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.29.985