Elevated factor IX activity is associated with an increased odds ratio for both arterial and venous thrombotic events

Elevations of factor IX (FIX) are thought to contribute to thrombotic risk, but this has not been well characterized. We retrospectively sought to determine whether elevated FIX levels are a risk factor for thrombosis in 81 adult subjects younger than 65 years (mean, 47 years) who were referred for...

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Bibliographic Details
Published in:American journal of clinical pathology 2013-11, Vol.140 (5), p.680-685
Main Authors: Heikal, Nahla M, Murphy, Karla K, Crist, Ronda A, Wilson, Andrew R, Rodgers, George M, Smock, Kristi J
Format: Article
Language:English
Subjects:
Adult
Cerebral Arteries - metabolism
Cerebral Arteries - pathology
Factor IX - metabolism
Female
Humans
Ischemic Attack, Transient - epidemiology
Ischemic Attack, Transient - metabolism
Ischemic Attack, Transient - pathology
Male
Middle Aged
Odds Ratio
Retrospective Studies
Risk Factors
Utah - epidemiology
Venous Thromboembolism - epidemiology
Venous Thromboembolism - metabolism
Venous Thromboembolism - pathology
Young Adult
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Summary:Elevations of factor IX (FIX) are thought to contribute to thrombotic risk, but this has not been well characterized. We retrospectively sought to determine whether elevated FIX levels are a risk factor for thrombosis in 81 adult subjects younger than 65 years (mean, 47 years) who were referred for evaluation of a hypercoagulable state. Patients were classified by arterial transient ischemic attack/stroke (TIA/stroke, n = 62) or venous thromboembolism (VTE, n = 19) events. FIX activity testing was performed on all 81 subjects and a reference group of 40 healthy individuals. Thirteen (21%) of 62 subjects with TIA/stroke and 5 (26%) of 19 subjects with VTE had elevated FIX activity. Odds ratios for TIA/stroke and VTE in subjects with elevated FIX activity were 3.7 (95% confidence interval [CI], 0.76-17.65) and 6.8 (95% CI, 1.18-39.07), respectively. Our findings suggest an association between elevated FIX levels and both arterial and venous thrombotic events.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCPAGOR4Q2IIKUG