Effects of two different immunotherapies on triple negative breast cancer in animal model

•Spontaneous breast cancer TA2 mouse was used as model of TNBC.•Tumor immunotherapy manifested strong killing activity against TNBC.•The effect of GM-CSF combined with antigens and CpG was better than DC–CIK cells. The ability of immune system to react specifically against tumors inspirited the stud...

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Bibliographic Details
Published in:Cellular immunology 2013-07, Vol.284 (1-2), p.111-118
Main Authors: Liu, Xiaoyi, Hu, Jianxia, Cao, Weihong, Qu, Huili, Wang, Yu, Ma, Zhongliang, Li, Funian
Format: Article
Language:English
Subjects:
Animals
Breast cancer
CpG
Cytokine-Induced Killer Cells - immunology
Cytokines - blood
DC/CIK cells
Dendritic Cells - immunology
Disease Models, Animal
Female
Flow Cytometry
GM-CSF
Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology
Immunotherapy
Immunotherapy - methods
Immunotherapy, Adoptive
Kaplan-Meier Estimate
Mammary Neoplasms, Experimental - immunology
Mammary Neoplasms, Experimental - therapy
Mice
Oligodeoxyribonucleotides - pharmacology
Random Allocation
Triple negative breast cancer
Triple Negative Breast Neoplasms - immunology
Triple Negative Breast Neoplasms - therapy
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Summary:•Spontaneous breast cancer TA2 mouse was used as model of TNBC.•Tumor immunotherapy manifested strong killing activity against TNBC.•The effect of GM-CSF combined with antigens and CpG was better than DC–CIK cells. The ability of immune system to react specifically against tumors inspirited the study of triple negative breast cancer (TNBC) immunotherapies. Sixty spontaneous breast cancer TA2 mice were randomly divided into three groups: GM-CSF group, with therapy of granulocyte–macrophage colony-stimulating factor (GM-CSF) combined with breast cancer stem cells associated antigens and cytosine–phosphorothioate–guanine oligodeoxynucleotides (CpG-ODNs); DC–CIK group, with infusions of dendritic cells/cytokine-induced killer (DC/CIK) cells; and PBS group as controls. After therapy, the cellular immunity of mice in GM-CSF group and DC–CIK group was obviously increased, especially for GM-CSF group (P
ISSN:0008-8749
1090-2163
DOI:10.1016/j.cellimm.2013.07.018