Relationship of Blood Levels of Inflammatory and Destructive Biomarkers in Coronary Atherosclerosis with Long-Term Results of Surgical Revascularization

The relationships between blood levels of inflammatory and destructive biomarkers (TNF-α, IL-1β, IL-6, IL-8, soluble CD40 ligand, high-sensitivity C-reactive protein, endothelial adhesion molecules, matrix metalloproteinase 3 and 9 and their tissue inhibitor type 1) were studied in men with coronary...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-07, Vol.155 (3), p.314-317
Main Authors: Ragino, Yu. I., Chernyavskiy, A. M., Tsimbal, S. Yu, Shcherbakova, L. V., Polonskaya, Ya. V., Kashtanova, E. V.
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Atherosclerosis
Biological markers
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
C-reactive protein
Cell Biology
Coronary artery bypass
Coronary Artery Disease - blood
Coronary Artery Disease - surgery
Coronary heart disease
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Humans
Inflammation - blood
Internal Medicine
Laboratory Medicine
Male
Middle Aged
Myocardial Revascularization - methods
Pathology
Russia
Treatment Outcome
Tumor necrosis factor
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Summary:The relationships between blood levels of inflammatory and destructive biomarkers (TNF-α, IL-1β, IL-6, IL-8, soluble CD40 ligand, high-sensitivity C-reactive protein, endothelial adhesion molecules, matrix metalloproteinase 3 and 9 and their tissue inhibitor type 1) were studied in men with coronary atherosclerosis before and 5 years after coronary artery bypass surgery. In men with unfavorable course of coronary atherosclerosis in the delayed period, the initial blood levels of C-reactive protein and TNF-α by 1.7 and 3.0 times surpassed those in patients with favorable course of the disease. Associations were revealed between elevated blood content of high-sensitivity C-reactive protein ( p =0.01, odds ratio of 1.33) and IL-8 ( p =0.02, odds ratio of 1.02) and deaths in the delayed period; IL-6 ( p =0.01, odds ratio of 1.02) and cases of myocardial infarction; C-reactive protein ( p =0.02, odds ratio of 1.24) and unfavorable course of the delayed period in general (death, myocardial infarction, worsening of angina pectoris functional class).
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2142-0