Ultra-compliant neural probes are subject to fluid forces during dissolution of polymer delivery vehicles

Ultra-compliant neural probes implanted into tissue using a molded, biodissolvable sodium carboxymethyl cellulose (Na-CMC)-saccharide composite needle delivery vehicle are subjected to fluid-structure interactions that can displace the recording site of the probe with respect to its designed implant...

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Main Authors: Rakuman, Wassim Ferose Habeeb, Xiao Chuan Ong, Tetikol, H. Serhat, Khilwani, R., Cui, X. Tracy, Ozdoganlar, O. Burak, Fedder, Gary K., Gilgunn, Peter J.
Format: Conference Proceeding
Language:English
Subjects:
In vitro
Microscopy
Needles
Polymers
Probes
Vehicles
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creator Rakuman, Wassim Ferose Habeeb
Xiao Chuan Ong
Tetikol, H. Serhat
Khilwani, R.
Cui, X. Tracy
Ozdoganlar, O. Burak
Fedder, Gary K.
Gilgunn, Peter J.
description Ultra-compliant neural probes implanted into tissue using a molded, biodissolvable sodium carboxymethyl cellulose (Na-CMC)-saccharide composite needle delivery vehicle are subjected to fluid-structure interactions that can displace the recording site of the probe with respect to its designed implant location. We applied particle velocimetry to analyze the behavior of ultra-compliant structures under different implantation conditions for a range of CMC-based materials and identified a fluid management protocol that resulted in the successful targeted depth placement of the recording sites.
doi_str_mv 10.1109/EMBC.2013.6609809
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identifier ISSN: 1094-687X
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subjects In vitro
Microscopy
Needles
Polymers
Probes
Vehicles
title Ultra-compliant neural probes are subject to fluid forces during dissolution of polymer delivery vehicles
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