Survivin expression can predict the effect of chemoradiotherapy for advanced lower rectal cancer

Background Chemoradiotherapy (CRT) has been used to improve local control and survival in patients with advanced rectal carcinoma. However, a significant proportion of patients show poor response to adjuvant CRT. We thus investigated the usefulness of survivin expression as a predictive marker of th...

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Bibliographic Details
Published in:International journal of clinical oncology 2013-10, Vol.18 (5), p.869-876
Main Authors: Takasu, Chie, Shimada, Mitsuo, Kurita, Nobuhiro, Iwata, Takashi, Sato, Hirohiko, Nishioka, Masanori, Morimoto, Shinya, Yoshikawa, Kozo, Miyatani, Tomohiko, Kashihara, Hideya, Utsunomiya, Tohru, Uehara, Hisanori
Format: Article
Language:English
Subjects:
Aged
Biopsy
Cancer
Cancer Research
Chemoradiotherapy
Chemotherapy
Combined Modality Therapy
Female
Gene expression
Humans
Inhibitor of Apoptosis Proteins - biosynthesis
Inhibitor of Apoptosis Proteins - genetics
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - radiotherapy
Oncology
Original Article
Preoperative Period
Prognosis
Rectal Neoplasms - drug therapy
Rectal Neoplasms - genetics
Rectal Neoplasms - pathology
Rectal Neoplasms - radiotherapy
Rectal Neoplasms - surgery
Surgical Oncology
Treatment Outcome
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Summary:Background Chemoradiotherapy (CRT) has been used to improve local control and survival in patients with advanced rectal carcinoma. However, a significant proportion of patients show poor response to adjuvant CRT. We thus investigated the usefulness of survivin expression as a predictive marker of the CRT response and its characteristics. Methods Forty-three patients with lower rectal cancer who underwent CRT were investigated. All patients received preoperative CRT consisting of TS-1 concurrent with 40 Gy of pelvic irradiation followed by curative resection. The relationship between clinical response, or pathological response, and the expression of survivin of pre-CRT biopsy specimens was evaluated by immunohistochemistry and compared with post-CRT expression. Results Positive expression of survivin was observed in 26 of 43 patients (60 %) in pre-CRT specimens. Survivin was positively expressed in 77 % of stable disease cases, and 43 % of partial response ( p  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-012-0470-0