Asymmetric Diboration of Terminal Alkenes with a Rhodium Catalyst and Subsequent Oxidation: Enantioselective Synthesis of Optically Active 1,2-Diols

Pin it down: A highly enantioselective diboration of terminal alkenes with chiral 1 and bis(pinacolato)diboron (B2pin2) was realized. Subsequent oxidation of the diboron adducts with sodium peroxoborate readily gave the corresponding optically active 1,2‐diols in high yields and high enantioselectiv...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-10, Vol.52 (42), p.11011-11015
Main Authors: Toribatake, Kenji, Nishiyama, Hisao
Format: Article
Language:English
Subjects:
asymmetric catalysis
boron
diols
enantioselectivity
rhodium
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Summary:Pin it down: A highly enantioselective diboration of terminal alkenes with chiral 1 and bis(pinacolato)diboron (B2pin2) was realized. Subsequent oxidation of the diboron adducts with sodium peroxoborate readily gave the corresponding optically active 1,2‐diols in high yields and high enantioselectivities.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201305181