Tipepidine activates VTA dopamine neuron via inhibiting dopamine D2 receptor-mediated inward rectifying K+ current

Highlights • Tipepidine inhibited DA D2 receptor-mediated GIRK channel currents in VTA neurons. • Tipepidine activated single VTA neurons inhibited by dopamine. • Tipepidine increased double immunopositive cells for TH and c-Fos in VTA. • The results show a part of mechanisms for novel antidepressan...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2013-11, Vol.252, p.24-34
Main Authors: Hamasaki, R, Shirasaki, T, Soeda, F, Takahama, K
Format: Article
Language:English
Subjects:
acutely dissociated neuron
Animals
Antidepressive Agents - pharmacology
Biological and medical sciences
dopamine
Dopaminergic Neurons - drug effects
Dopaminergic Neurons - metabolism
Fundamental and applied biological sciences. Psychology
G protein-coupled inwardly rectifying potassium channel
G Protein-Coupled Inwardly-Rectifying Potassium Channels - drug effects
G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism
Immunohistochemistry
Neurology
patch clamp
Patch-Clamp Techniques
Piperidines - pharmacology
Rats
Rats, Wistar
Receptors, Dopamine D2 - drug effects
Receptors, Dopamine D2 - metabolism
tipepidine
ventral tegmental area
Ventral Tegmental Area - drug effects
Ventral Tegmental Area - metabolism
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Tipepidine inhibited DA D2 receptor-mediated GIRK channel currents in VTA neurons. • Tipepidine activated single VTA neurons inhibited by dopamine. • Tipepidine increased double immunopositive cells for TH and c-Fos in VTA. • The results show a part of mechanisms for novel antidepressant effect of tipepidine.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.07.044