New Pterosin Sesquiterpenes and Antitubercular Constituents from Pteris ensiformis

Two new pterosin sesquiterpenes, (2S)‐13‐hydroxypterosin A (1) and (2S,3S)‐12‐hydroxypterosin Q (2), were isolated from the whole plants of Pteris ensiformis, together with six known compounds. The structures of 1 and 2 were determined through extensive 1D/2D‐NMR and MS analyses. Compound 2 exhibite...

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Bibliographic Details
Published in:Chemistry & biodiversity 2013-10, Vol.10 (10), p.1903-1908
Main Authors: Chen, Jih-Jung, Wang, Tai-Chi, Yang, Chieh-Kai, Liao, Hsiang-Ruei, Sung, Ping-Jyun, Chen, Ih-Sheng, Cheng, Ming-Jen, Peng, Chien-Fang, Chen, Jinn-Fen
Format: Article
Language:English
Subjects:
Antitubercular activity
Antitubercular Agents - chemistry
Antitubercular Agents - isolation & purification
Antitubercular Agents - pharmacology
Indans - chemistry
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Conformation
Mycobacterium tuberculosis - drug effects
Plant Extracts - chemistry
Plant Extracts - pharmacology
Pteris - chemistry
Pteris - metabolism
Pteris ensiformis
Pterosin sesquiterpenes
Sesquiterpenes
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
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Summary:Two new pterosin sesquiterpenes, (2S)‐13‐hydroxypterosin A (1) and (2S,3S)‐12‐hydroxypterosin Q (2), were isolated from the whole plants of Pteris ensiformis, together with six known compounds. The structures of 1 and 2 were determined through extensive 1D/2D‐NMR and MS analyses. Compound 2 exhibited antitubercular activity (MIC 6.25 μg/ml) against Mycobacterium tuberculosis H37Rv in vitro.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201300072