Identification of Silver Nanoparticles in the Small Intestinal Mucosa, Liver, and Spleen of Rats by Transmission Electron Microscopy

The effects of water-dispersed Ag nanoparticles on the small intestinal mucosa, liver, and spleen of rats were studied by transmission electron microscopy. Acute experiments demonstrated penetration of Ag nanoparticles injected into the isolated intestinal loop into the intestinal mucosa, liver, and...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-06, Vol.155 (2), p.236-241
Main Authors: Platonova, T. A., Pridvorova, S. M., Zherdev, A. V., Vasilevskaya, L. S., Arianova, E. A., Gmoshinski, I. V., Khotimchenko, S. A., Dzantiev, B. B., Popov, V. O., Tutelyan, V. A.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Electron microscopy
Gastrointestinal system
Hepatocytes - cytology
Internal Medicine
Intestinal Mucosa - cytology
Intestine, Small - cytology
Laboratory Medicine
Liver
Liver - cytology
Male
Metal Nanoparticles - chemistry
Microscopy, Electron, Transmission
Mitochondria
Nanoparticles
Nanotechnologies
Pathology
Peyer's Patches - cytology
Rats
Rats, Wistar
Silver - chemistry
Spleen - cytology
Tissue Distribution
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Summary:The effects of water-dispersed Ag nanoparticles on the small intestinal mucosa, liver, and spleen of rats were studied by transmission electron microscopy. Acute experiments demonstrated penetration of Ag nanoparticles injected into the isolated intestinal loop into the intestinal mucosa, liver, and splenic tissues. Ultrastructural changes (lobed nucleus, megamitochondria) were found in the studied organs. These data indicated that injection of waterdispersed Ag nanoparticles into the gastrointestinal tract was followed by their penetration through the epithelium of the small intestinal mucosa into other organs, e.g. into the liver and spleen. This fact is essential for evaluation of potential risks of the nanoparticle effects on human health and environment.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2122-4