Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats

Highlights • Fluoxetine produces local nociception and spinal antinociception. • Fluoxetine-induced nociception was prevented by 5-HT2A/2B/2C/3/4/6/7 antagonists. • Fluoxetine-induced nociception was unaltered by 5-HT1A/1B/1D/5A antagonists. • Fluoxetine-induced antinociception was prevented by 5-HT...

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Bibliographic Details
Published in:Neuroscience 2013-11, Vol.252, p.396-409
Main Authors: Cervantes-Durán, C, Rocha-González, H.I, Granados-Soto, V
Format: Article
Language:English
Subjects:
5-HT receptors
Animals
Biological and medical sciences
Female
fluoxetine
Fluoxetine - pharmacology
formalin test
Fundamental and applied biological sciences. Psychology
mechanism of action
Neurology
nociception
Pain - metabolism
Peripheral Nervous System - drug effects
Peripheral Nervous System - metabolism
Rats
Rats, Wistar
Receptors, Serotonin - metabolism
Serotonin Antagonists - pharmacology
Serotonin Uptake Inhibitors - pharmacology
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Spinal Cord - drug effects
Spinal Cord - metabolism
Vertebrates: nervous system and sense organs
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Summary:Highlights • Fluoxetine produces local nociception and spinal antinociception. • Fluoxetine-induced nociception was prevented by 5-HT2A/2B/2C/3/4/6/7 antagonists. • Fluoxetine-induced nociception was unaltered by 5-HT1A/1B/1D/5A antagonists. • Fluoxetine-induced antinociception was prevented by 5-HT1A/1B/1D/5A antagonists. • Fluoxetine-induced antinociception was unaltered by 5-HT2/3/4/6/7 antagonists.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.08.022